Kamal’s follow-up to Dasavatharam with Saran seems to be confirmed now. Saran talks of working with Kamal:

Recalling his early days, Saran says,” Working with Kamal Haasan in Vasool Raja MBBS was a relishing experience. We are coming together next year.”
“Though Vasoolraja was a remake, I had made certain alterations to the story to suit the local audience. You need experience to handle an actor of Kamal’s calibre and years of working under KB sir certainly came in handy,” says Saran, who also adds that he has no plans of remaking the Hindi-sequel Lage Raho Munnabhai.